IJDDC

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IJDDC

IJDDC

International Journal Diabetes in Developing Countries

July-August, 2023 • Vol. 43 • # 4

Glycemic control among Iranian people with type 2 diabetes: a systematic review and meta-analysis

Glycemic control reduces the risk of cardiovascular complications among people with diabetes. However, the current status of glycemic control is uncertain among Iranian people with diabetes. This study aims to systematically review the studies on the status of glycemic control among people with type 2 diabetes in Iran.

Prevalence and outcomes of gestational diabetes mellitus in Indian women: Insights from a large real-world study over ten years at tertiary care research institute

Gestational diabetes mellitus (GDM) is commonly noted during the second trimester of pregnancy. There is limited clinical evidence for the diagnosis of GDM during the third trimester of pregnancy, particularly in Indian pregnant women.

Comparison of metformin and insulin therapy for the treatment of gestational diabetes mellitus - a randomised controlled trial

Insulin therapy though time-tested and effective option requires a certain degree of expertise (or training) and storage precautions. Metformin is cheap, orally taken, and does not cause hypoglycemia. Controversy exists regarding safety and efficacy of metformin therapy during pregnancy.

Evaluation of the efficiency of insulin degludec/insulin aspart therapy in controlling hyperglycemia and hypoglycemia in patients with type 2 diabetes mellitus: a real-life experience

Insulin degludec/insulin aspart (IDegAsp) is the first dual combination that acts separately (basal and prandial actions). Different insulin regimens can be switched to IDegAsp. Several studies have been conducted evaluating the effectiveness and safety of IDegAsp. The purpose of this real-life study was to determine the effects of IDegAsp on metabolic control and hypoglycemia in patients who were switched from different insulin regimens to IDegAsp therapy.

The prevalence and risk factors of retinopathy and nephropathy in prediabetic population

There are very few studies in which retinopathy is determined by fundus fluorescein angiography (FFA) in prediabetics. We aimed to determine the frequency of retinopathy with a sensitive method and its relation to nephropathy in the prediabetic population.

Diabetes in southern Iran: a 16-year follow-up of mortality and years of life lost

Diabetes mellitus (DM) had one of the highest global disease burdens and is associated with premature morbidity, mortality, and reduced life expectancy. There has been little study regarding mortality and years of life lost attributable to DM in low-and-middle income countries.

Maternally inherited diabetes and deafness (MIDD)-a series of case reports

Maternally inherited diabetes and deafness (MIDD) is a rare form of diabetes, caused by a mutation in the mitochondrial DNA (mtDNA) which impairs mitochondrial function by decreasing the efficiency of the Leucine transfer ribonucleic acid (tRNA) in adding amino acids to developing proteins.

Role of ChREBP and SREBP-1c in gestational diabetes: two key players in glucose and lipid metabolism

Gestational diabetes mellitus (GDM) is any degree of glucose intolerance diagnosed during pregnancy. Metabolic abnormalities in GDM are associated with pancreatic -cell destruction and decreased insulin sensitivity. Carbohydrate-responsive element-binding protein (ChREBP) and sterol regulatory element-binding protein-1c (SREBP-1c) are two transcription factors that play a key role in carbohydrate and lipid metabolism homeostasis. Our aim in this study was to elucidate the role of these proteins in GDM

Plasma carnitine, choline, γ-butyrobetaine, and trimethylamine-N-oxide, but not zonulin, are reduced in overweight/obese patients with pre/diabetes or impaired glycemia

Zonulin, carnitine, choline, -butyrobetaine (-BB), and trimethylamine-N-oxide (TMAO) are intricately involved in metabolic anomalies and type 2 diabetes mellitus (T2D). This study aimed to compare and correlate the plasma levels of zonulin, carnitine, choline, -butyrobetaine, and TMAO, along with the adiposity, atherogenicity, surrogate insulin resistance (sIR), and proinflammatory hematological indices of newly diagnosed drug-naive prediabetic and diabetic patients vs. apparently healthy normoglycemic controls

The relationship between oxytocin-copeptin levels and cognition-anxiety in patients with type I diabetes mellitus

Type I diabetes mellitus can lead to the development of cognitive dysfunction and anxiety due to chronic hyperglycemia, recurrent hypoglycemia, and micro - and macrovascular complications. It is known that oxytocin and copeptin have effects on neuropsychiatric activities such as learning, memory, and social adaptation and have anxiolytic properties. In this study, we aimed to search the relationship between oxytocin and copeptin levels and cognition and anxiety in patients with type I diabetes mellitus.

Increased skin autofluorescence of advanced glycation end products (AGEs) in subjects with cardiovascular risk factors

As a clinical and non-invasive tool, the AGE Reader measures skin autofluorescence (SAF) to estimate the accumulation of advanced glycation end products (AGEs) in the skin. Accumulation of AGEs has been implicated in several inflammation-associated diseases, including diabetes and cardio-metabolic diseases. This study aimed to assess SAF in subjects with and without cardiovascular risk (CVR) factors and examine the association between SAF and various bio-clinical parameters.

Tumor necrosis factor-alpha and high sensitivity C-reactive protein in young patients with diabetes mellitus

Inflammatory markers like tumor necrosis factor- (TNF-) and high-sensitivity C-reactive protein (hsCRP) have been thought to be associated with diabetes mellitus (DM). But their role in the development of diabetes in young is yet to be established