Banu Boyuk, Rukiye Nurdan Avci, Seydahmet Akin, Hande Erman, Emine Koroglu, Ozcan Keskin
Keywords
Atherosclerosis • Diabetes • Helicobacter pylori
Abstract
Background In this study, the aim was to investigate the effect of Helicobacter pylori (Hp) presence on carotid intima-media thickness, which is an early sign of atherosclerosis in type 2 diabetic patients.
Methods This study is a retrospective study conducted with type 2 diabetic patients who were followed up in the gastroenterology and diabetes outpatient clinic. The relationship between the presence of Hp and laboratory findings, demographic and clinical characteristics, intima-media thickness and pathology findings were analyzed in patients who underwent endoscopy for dyspepsia.
Results A total of 73 cases meeting the inclusion criteria, 32 males (43.8%) and 41 females (56.2%), between 42 and 83 years with an average age of 59 ± 10 years were included in the study. Of the cases, 31 (42.4%) were found to be Hp positive. Among the participants, the presence of carotid plaque was observed in 17 (40.5%) of the Hp negative patients and 16 (51.6%) of the Hp positive patients (p = 0.476). The presence of Hp increases the left carotid intimamedia thickness (CIMT) by 0.092 mm (p = 0.018) at 95% significance level on the left. In addition, age has an effect on the increase of left
CIMT (β = 0.007, p < 0.001) and right CIMT (β = 0.009, p < 0.001). LDL-C levels have an effect on right CIMT (β = 0.001, p = 0.003).
Conclusion We demonstrated that the presence of Hp increases the carotid intima-media thickness in patients with type 2 diabetes. In addition, LDL-C and age have an increasing effect on intima-media thickness.
