Edlaine Rijo Costa, Thales Nascimento Castro, Rita de Cássia Elias Estrela, José Carlos Saraiva Gonçalves & Glorimar Rosa
Keywords
Dietary fiber • Hypoglycemic agents • Diabetes mellitus • Drug-food interactions • Absorption
Abstract
Purpose Dietary fibers and hypoglycemic drugs can be used concomitantly in the treatment of diabetes mellitus. We aimed to perform this review in order to evaluate whether scientific evidence is available regarding the interaction between these components and whether these interactions alter drug absorption.
Methods We conducted a search of the literature for controlled clinical trials that evaluated the occurrence and clinical relevance of interactions between dietary fibers and hypoglycemic drugs. Six databases were searched from inception to April 20, 2020 and trials were eligible for inclusion if they measured changes in drug absorption parameters.
Results In three studies, there were interactions between dietary fibers and hypoglycemic drugs, causing alterations in drug absorption. The other two studies had no significant changes in absorption pharmacokinetic parameters.
Conclusions The physicochemical characteristics of the dietary fiber used, the chemical structure of the drug, and the pharmaceutical form administered are determining factors for the occurrence of alterations in drug absorption.
