Amir Hossein Mahdizade, Seyed Sobhan Bahreiny, Mohammad‑Navid Bastani, Mohammad Reza Dabbagh, Mojtaba Aghaei, Fardin Ali Malayeri, Aryan Yousefi Fard, Eskandar Taghizadeh
Keywords
Gestational diabetes mellitus • Genetic polymorphism • CDKAL1 rs7754840 • Meta-analysis
Abstract
Objective Gene polymorphisms CDKAL1 (rs7754840) have been related to type 2 diabetes mellitus, which may partially define the common genetic background with gestational diabetes mellitus (GDM). The aim of this study is to investigate the association between CDKAL1 polymorphism and susceptibility to GDM.
Methods In this study and meta-analysis, we conducted a systematic search in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and Google scholar. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the association between CDKAL1 (rs7754840) polymorphisms and susceptibility to GDM in four genetic models. Statistical analysis was performed by Comprehensive Meta-Analysis (CMA) v3.7z software.
Results A total of 13,307 participants from 11 original study were included in this study. We identified a significant relationship between the CDKAL1 (rs7754840) gene polymorphism and GDM in the study population through allelic models (C vs. G: OR = 1.29, 95% CI = 1.16–1.44, p = 0.00), homozygous genetic models (CC vs. GC: OR = 1.50, 95% CI = 1.28–1.75, p = 0.00), recessive models (CC vs. GG + GC: OR = 0.67, 95% CI = 0.57–0.79, p = 0.00), and dominant genetic models (CC + GC vs. GG: OR = 1.35, 95% CI = 1.17–1.56, p = 0.00). On the contrary, there is no significant association between the CDKAL1 gene polymorphism and susceptibility to GDM in heterozygous models (GC vs. GG:
OR = 1.01, 95% CI = 0.92–1.12, p = 0.82).
Conclusion The results provided evidence that CDKAL1 (rs7754840) gene polymorphism is associated with the susceptibility of GDM in women.
